1 article tagged with "methylation"
SAMe (S-adenosyl methionine) is one of the most clinically studied natural compounds for depression, with systematic reviews showing efficacy comparable to prescription antidepressants and fewer side effects. This guide covers the science behind SAMe's methylation-driven antidepressant mechanism, evidence-based dosing protocols (200–1,600 mg/day), critical contraindications including bipolar disorder, and realistic expectations for this effective but expensive supplement.
